CNY 149 13th Street | Charlestown, MA 02129, USA
Our lab comprises staff researchers, postdocs, and students from diverse backgrounds (Physics, Computer Science, Molecular Biology, and Medicine). Additionally, our team is part of a lively community of computational labs at MGH Cancer Center and the Department of Biomedical Informatics at HMS and an integral part of the Investigational Cancer Therapeutics team at Termeer Center. You can read more about our broader community here.
Doga is the Principal Investigator of Gulhan Lab at Mass General Hospital (MGH) Cancer Center and a Member of the Faculty of Medicine at HMS. She received her Bachelor of Science degree from Bilkent University's Physics Department. She completed her Ph.D. in high-energy physics at the Massachusetts Institute of Technology and worked as a Research Fellow at CERN. After transitioning to biomedical informatics, she joined Park Lab at the Department of Biomedical Informatics at HMS as a postdoctoral fellow. She studied mutational processes in cancer using signature analysis techniques. She contributed new algorithms to this emerging field that expanded its clinical applications by enabling signature prediction from targeted gene panels and robust signature discovery and assignments from whole exome and genome datasets. Her latest work focused on understanding the immunogenomic and molecular characteristics of tumors with repair deficiencies. Her research program is dedicated to developing a comprehensive suite of tools for deciphering cancer genomes, aimed at personalized oncology. This includes the creation of both statistical and machine-learning methods designed specifically for analyzing mutational signatures, timing mutations, and tracking tumor evolution.
Yoo-Na obtained her bachelor’s degree in Economics and Biology from Columbia University in 2011. Following that, she pursued Medicine at Yonsei University College of Medicine, where she completed my internship and residency in Obstetrics and Gynecology at Yonsei University’s Severance Hospital in South Korea.
After completing my residency, she worked as a biomedical analyst in 2020 at UCL/EUTOPS, focusing on epigenetics research using microarray data from various types of gynecological cancer samples, including cervical swabs, buccal swabs, and whole blood. Subsequently, she returned to my clinical role as a fellow in Gynecologic Oncology at Severance Hospital. During her fellowship, she actively participated in running clinical trials and analyzing genomic and transcriptomic data from gynecological cancer samples, including circulating tumor DNA samples.
Sangmi (Sandra) Lee hold a Ph.D. in Chemical and Biomolecular Engineering from Korea Advanced Institute of Science and Technology (KAIST), South Korea. Specializing in systems biology, Sandra leverages her expertise to characterize cancer metabolism and develop innovative cancer treatments using network modeling, big data and artificial intelligence. Her work in computational biology, marked by a commitment to integrating multi-omics data and mathematical methodologies, reflects a steady commitment to addressing medical challenges within the field of cancer research. When she’s not in the lab, Sandra is an avid yogi who also enjoys swimming and playing squash to maintain her balance and well-being.
Fenisha was born and raised in India and decided to leave the country at an age of 18. She moved to Miami for my undergraduate education. She pursued a BS in Electrical Engineering with a minor in chemistry and biology at University of Miami. She later decided to pursue a masters degree in Biomedical engineering with a focus on bioinformatics at Columbia University. This is where she dwelled into the world of genetics and transcriptomics. Her work focussed on big data analysis and single cell RNA seq. She also worked at different labs at Columbia exploring and enhancing analysis techniques like machine learning approaches, statistical methods. Now, her focus is to keep applying, developing and learning novel bioinformatics tools to derive important informative insights from biological datasets.
Driven by a passion for advancing medical science, Nick joined Massachusetts General Hospital (MGH) as a Translational Research Manager in the Termeer Center for Targeted Therapies. He collaborates on projects to uncover resistance mechanisms to novel targeted cancer therapies. His responsibilities include managing a non-therapeutic research protocol that focuses on the serial collection of biospecimens from blood draws, biopsies, and autopsies, contributing to developing more effective cancer treatments. Nick's academic background includes a Bachelor's degree in Chemistry from the College of the Holy Cross and an MBA in Healthcare Management. Eager to deepen his expertise, he is currently pursuing a Master’s degree in Bioinformatics at Northeastern University. As part of his co-op experience, Nick has joined the Gulhan lab, where he analyzes genomic and transcriptomic data from the Termeer Rapid Autopsy Program.
Are you interested in our research and want to be a part of the team?
CNY 149 13th Street | Charlestown, MA 02129, USA
© Gulhan Lab
